Cyanobacteria as a valuable source of antiviral, antibacterial and antifungal compounds ? an overview
Mukherjee, Gargi; Nayak, Bikram Kumar; Das, Debabrata
Cyanobacteria, or blue green (BGA) algae are gram-negative, phototrophic, nitrogen fixing, ubiquitous, prokaryotic organisms, known to be a promising source of renewable fuel, biofertilizers, pigments, colorants, proteins and vitamins. BGA have also been reported as a huge repertoire of novel, bioactive natural compounds. The biologically active secondary metabolites include lipopeptides, amino acids, fatty acids, amides, alkaloids and polyketides etc possessing a wide range of cytotoxic, antiviral, antibiotic, antimycotic, multi-drug resistance reversing, immunosuppressive, anti-inflammatory, enzyme inhibiting properties. Cyanobacterial species accumulate a high amount of these bioactive compounds in their biomass, which leach into their surrounding environment. The exploration of cyanobacteria as sources of highly diverse secondary metabolites is evolving as a promising field leading to the emergence of new pharmaceutically important compounds. The present review deals with different aspects of numerous antiviral, antibacterial and antifungal compounds reported from various cyanobacterial strains including their chemical nature, sources and action.