Original paper

ACE Insertion/Deletion Polymorphism and Its Relationships to the Components of Metabolic Syndrome in Elderly Slovaks

Siváková, Daniela; Lajdová, Alica; Bašistová, Zuzana; Cvíčelová, Marta; Blažíček, Pavel

Anthropologischer Anzeiger Volume 67 No. 1 (2009), p. 1 - 11

published: Apr 8, 2009

DOI: 10.1127/0003-5548/2009/0001

BibTeX file

ArtNo. ESP140006701001, Price: 29.00 €

Download preview PDF Buy as PDF

Abstract

The purpose of this study was to assess clustering of Metabolic Syndrome components in aged Slovaks, and to investigate whether insertion/deletion (I/D) polymorphism of the human angiotensin-converting enzyme (ACE) gene is associated with this syndrome. Data were available from 374 Slovak participants (200 females and 174 males) ranging in age between 60 and 90 years. ACE I/D polymorphism was determined by PCR amplification of the ACE gene sequence. Metabolic Syndrome was diagnosed according to criteria in the NCEP ATP-III. Elderly males and females differ significantly in the prevalence of Metabolic Syndrome (females 45.1 %, males 24.8 %). The males and females including subjects with and without metabolic syndrome, respectively, did not differ significantly in the three genotype distributions (p = 0.603 and p = 0.247). The allele frequencies (D = 0.5483, I = 0.4517) in the entire sample fell within the Hardy-Weinberg equilibrium. There was no confirmed association between ACE genotype and phenotypic variation in the recognized risk components for Metabolic Syndrome in elderly Slovaks. Among other factors which may induce a difference in Metabolic Syndrome, significant effect was detected for sex, BMI, HDL, TG, glucose and the ApoB/ApoA1 ratio.

Keywords

ace i/d polymorphismmetabolic syndromerisk factorselderly slovaks