Inheritance of dermatoglyphic diversity in 500 Indian pedigrees: Complex segregation analysis
Karmakar, Bibha; Malkin, Ika; Kobyliansky, Eugene
The main goal of the present communication is to determine the mode of inheritance of dermatoglyphic diversity traits through complex segregation analyses (genetic model fittings). The data consists of a large ethnically homogeneous sample of 500 Indian pedigrees (2435 individuals) of two generations. Principal component analysis, familial correlations and segregation analysis (package MAN-5) were used. A little genetic effect obtained from familial correlations but no evidence of major gene contribution found to be involved. By segregation analysis of the traits- PC1_ Div, Div 9 and Div 11, both Mendelian and Environmental models were rejected (≪0.001) with the General model, i.e. despite the presence of significant inheritance (rejection of Environmental model), the nature of inheritance is more complex, than Mendelian model.