Original paper

Did Tutankhamun suffer from hypophosphatasia? ? A hypothetical approach

Brandt, Gerald

Anthropologischer Anzeiger Volume 70 No. 3 (2013), p. 249 - 260

published: Nov 1, 2013

DOI: 10.1127/0003-5548/2013/0322

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ArtNo. ESP140007003001, Price: 29.00 €

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Abstract

Between 2005 and 2010 new efforts have been undertaken to shed light on the life and death of Tutankhamun ? for the first time with the aid of modern scientific methods like CT scans and DNA analysis. The publication of a paper in the Journal of the American Medical Association in February 2010, that stated the famous pharaoh died of a combination of Malaria and Köhler's disease II, provoked objections from various sides. Based on new and existing findings, the author has developed the theory that Tutankhamun might, instead, have suffered from hypophosphatasia, an inherited metabolic disorder that affects especially the musculo-skeletal system in many ways. Hypophosphatasia (HPP) can be highly variable in its clinical manifestations and can be difficult to diagnose. The author has compiled both medical and archaeological findings to support his theory and suggests that existing DNA samples of Tutankhamun and other members of his family should be tested for defects on the ALPL gene.

Keywords

alpl genehypophosphatasiainherited metabolic disordertutankhamun